Description

Saccharomyces Boulardii

Lactose-free special strain of non-GMO Saccharomyces boulardii isolated from litchi fruits.

• Enhances microbial diversity 
• Promotes gut health 
• Supports gut immunity 
• Stabilizes stool consistency and frequency 
• Supports healthy gastrointestinal microbes in people with low stomach acid 
• High survivability; resistant to acid, bile, and heat 
• No refrigeration required
• Suitable for vegetarians, gluten-free, dairy-free, soy-free, and non-GMO 

Description

Saccharomyces boulardii is a non-GMO strain of Saccharomyces boulardii isolated from litchi fruits. The Saccharomyces boulardii contained in this product is dairy and lactose-free and does not require refrigeration. In contrast to other products that contain this organism, this product can be stored at room temperature for up to two years without going bad. 

Each serving of Saccharomyces boulardii contains 500 mg of the nonpathogenic yeast Saccharomyces boulardii (about 10 billion viable cells during production) . S. boulardii promotes microbial diversity, supports immune function, and supports gastrointestinal health.  As a general supplement for optimal gastrointestinal health, this strain is most studied for its effectiveness in preventing antibiotic-associated diarrhea. 

Antibiotic resistance

1. S. boulardii has been shown to be naturally antibiotic-resistant, so it can be given to patients receiving antibiotics. A study found that it stimulated sucrase, lactase, and maltase enzymes at the intestinal brush border (Ibid). This organism has the following probiotic properties: 

(a) Binding of enterohemorrhagic E coli and Salmonella; 

(b) Protecting the digestive mucosa; 

(c) Boosting the growth of gut bacteria that produce lactic acid; 

(d) Protection against Clostridium difficile toxins; and 

1. e) Stimulates mucosal immunity and gastrointestinal mucosa.

Saccharomyces boulardii is helpful for: 

• Diarrhea 
• Antibiotic-associated diarrhea 
• Traveler’s diarrhea 
• Imbalanced GI mucosal immune function 
• Restoration of optimal GI microflora and mucosal health 
• Dysbiosis 
• Opportunistic bacterial overgrowth 
• Opportunistic Candida and other yeast overgrowths 
• H. pylori 

Diarrhea and dysbiosis prevention

Different bacterial species are in equilibrium in the gut ecology, creating a complex system. Infectious disease and antibiotic treatment can disrupt this equilibrium (dysbiosis) and cause diarrhea. There is a possibility that antibiotic-associated diarrhea can give rise to Clostridium difficile diarrhea, a severe disorder that has an incredibly high relapse rate and is difficult to treat. Therefore, probiotics, particularly Saccharomyces boulardii, are becoming increasingly popular as antibiotic alternatives.

The outer membrane of S. boulardii is mannose-dominant, which allows them to bind to bacteria such as E. coli and Salmonella, which are responsible for diarrhea, especially traveler’s diarrhea. As a result of yeast’s large cell surface, many bacteria can bind to it, limiting their ability to bind to the epithelium of the intestinal tract. As a result, the bacteria will be eliminated in the stool.

Researchers obtained the results shown at right after administering a placebo to patients under antibiotic treatment. Despite the fact that S. boulardii is not capable of suppressing all antibiotic-associated diarrhea, a 50% reduction in risk is significant. 

Saccharomyces Boulardii to restore gut health

In the small intestine, S. boulardii preserves tight junctions, decreases inflammation & cytokine production, and incites increased levels of sIgA and immune defenses. In addition, S. boulardii adheres to pathogenic bacteria in the intestinal lumen thereby preventing their invasion of the system. 

Keep healthy microbe balanced

The presence of S. boulardii may be beneficial to the gut microbiome, as it competes with undesirable bacteria and yeasts to maintain the normal colonization of commensal (beneficial) species.

In addition to being a beneficial microbe, S. boulardii may help create a favorable environment for beneficial microbes and a hostile environment for pathogenic microbes. Therefore, certain medications may help reestablish a healthy microbiome. 

High survivability

The strain does not require refrigeration and is capable of withstanding bile, acidity, and heat in a harsh gastric environment. Researchers have extensively studied the potential benefits of this strain for promoting gastrointestinal health.

Promotes short-chain fatty acids production

It is believed that the cell wall of S. boulardii yeast has prebiotic properties due to the fact that it may stimulate the production of short-chain fatty acids (SCFAs), an important metabolite produced by the large intestine and a preferred energy source for intestinal cells. 

The SCFAs play multiple biochemical functions, including promoting a healthy inflammatory response in the gut, ensuring gut barrier integrity, and improving immunity in mucosal cells. It also promotes gut health and immune function.

Saccharomyces Boulardii is effective in eradicating H. pylori

Researchers found that S. boulardii may also be useful for eradicating H. pylori. An extensive review and meta-analysis conducted in 2015 found that adding S. boulardii to standard H. pylori eradication treatments increased eradication rates and reduced therapy-related side effects.

Another study in 2014 demonstrated that adding S. boulardii to standard psyllium husk treatment improved quality of life and histology in patients with IBS-D when compared to placebo with psyllium husk, although other studies failed to demonstrate the same effect. 

According to a small study of Crohn’s patients in remission, 37.5% had clinical relapses after six months of treatment with the NSAID mesalamine. In contrast, 6.25% after six months of treatment with mesalamine plus S. boulardii. The research suggested that a combination of S. boulardii and mesalamine also improved symptoms of IBS-D more than mesalamine alone: S. boulardii alone did not significantly improve symptoms, but mesalamine alone did not. 

Recommended Use:  

The recommended dosage is two capsules daily, or as directed by a health care practitioner